Morphogenic Effects of Halogenated Thymidine Analogues on Drosophila
نویسندگان
چکیده
منابع مشابه
Morphogenic effects of halogenated thymidine analogues on Drosophila. VI. Causal analysis of bromodeoxyuridine induced growth lesions.
Variations in the treatment conditions which affect the frequency of BUdR-induced morphogenic lesions in Drosophila melanogaster have been studied. By varying the concentrations of BUdR and FU, or by changing the duration of treatment, it has been demonstrated that increased incorporation of BUdR into DNA results in a concomitant increase in morphogenic lesions. A quantitative analysis of the d...
متن کاملMorphogenic effects of halogenated thymidine analogs on Drosophila. II. Incorporation of 5 -bromodeoxyuridine into DNA.
When 5-bromodeoxyuridine is fed to Drosophila larvae, a variety of morphogenic lesions are found in the hatching adults. Experiments were undertaken to determine whether 5-bromodeoxyuridine is incorporated into Drosophila DNA under the conditions which induce developmental modifications. Radioautographic techniques were used to examine the distribution of [aH lbromodeoxyuridine in Drosophila la...
متن کاملHalogenated thymidine analogues restore the expression of silenced genes without demethylation.
Transcriptional silencing of tumor suppressor genes by aberrant DNA methylation is a characteristic frequently observed in cancer cells. Therefore, reversing this process is a therapeutic target against cancer. In this study, we established a screening system for silencing inhibitors with cell lines transfected by a retroviral vector containing a luciferase gene. More than 100 nucleosides were ...
متن کامل5-Halogenated thymidine analogues induce a senescence-like phenomenon in HeLa cells.
We tested various thymidine analogues for induction of a senescence-like phenomenon in HeLa cells. CldU, BrdU, and IdU similarly induced the morphology of senescent cells and typical senescence markers. Thymidine analogues other than 5-halogenated forms caused only cell death. BrdU efficiently killed the cells in cooperation with irradiation with light and a brief treatment with Hoechst 33258, ...
متن کاملthe effects of error correction methods on pronunciation accuracy
هدف از انجام این تحقیق مشخص کردن موثرترین متد اصلاح خطا بر روی دقت آهنگ و تاکید تلفظ کلمه در زبان انگلیسی بود. این تحقیق با پیاده کردن چهار متد ارائه اصلاح خطا در چهار گروه، سه گروه آزمایشی و یک گروه تحت کنترل، انجام شد که گروه های فوق الذکر شامل دانشجویان سطح بالای متوسط کتاب اول passages بودند. گروه اول شامل 15، دوم 14، سوم 15 و آخرین 16 دانشجو بودند. دوره مربوطه به مدت 10 هفته ادامه یافت و د...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Differentiation
سال: 1975
ISSN: 0301-4681
DOI: 10.1111/j.1432-0436.1975.tb00853.x